HO-1 and Muscle Mitochondrial Dysfunction in Sepsis

Naval Military Medical University

Status: Unknown

Conditions: Atrophy; Sepsis

Treatments: Procedure: standard surgery for femoral fracture and muscle biopsy; Procedure: therapy according to SSC guidelines and muscle biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT02359240

CH1502

Details and patient eligibility

About

The current project was designed to examine dynamic changes in muscle wasting during sepsis. Researchers will focus the mitochondrial dysfunction of muscle cells and investigate the role of HO-1 in it. Researchers interested in identifying factors involved in the pathology of muscle wasting during sepsis.

Full description

Rapid muscle atrophy or muscle wasting occured to septic patients.Sepsis induced muscle wasting has become a severe, frequent, and persistent complication among critically ill patients. Multiple factors including ubiquitin-proteasome system, proinflammatory cytokines and oxidative stress contribute muscle proteolysis.

It is known that heme oxygenase-1 (HO-1) possesses a variety of functions like anti-inflammatory, antioxidative and anti-apoptosis effects. In order to investigate the mechanisms under the condition, researchers are going to examine the role of HO-1 in muscle atrophy during sepsis.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• sepsis, severe sepsis, septic shock
• clinical reason for fixation surgery of femoral fractures

Exclusion criteria

• no informed consent
• medical history of myopathy
• unintended weight loss before surgery or ICU admission
• chronic use of corticosteroids

Trial design

50 participants in 2 patient groups

sepsis

Description:

Patients with a diagnosis of sepsis or severe sepsis,immobilization for 3 days at least. Therapy according to the SSC guidelines will be applied. therapy according to SSC guidelines and muscle biopsy

Treatment:

Procedure: therapy according to SSC guidelines and muscle biopsy

Patients with femoral fractures

Description:

non septic patients with a femoral fracture,who need an fixation surgery.standard surgery for femoral fracture and muscle biopsy will be performed.

Treatment:

Procedure: standard surgery for femoral fracture and muscle biopsy