HO-1/CREB3 Modulates Golgi Stress in Patients With Sepsis

Tianjin Nankai Hospital

Status: Enrolling

Conditions: Sepsis

Treatments: Other: nothing

Study type: Observational

Funder types: Other

Identifiers

NCT06045780

NKYY_YXKT_IRB_2023_049_01

Details and patient eligibility

About

This study was an ambispective observational cohort study that included sepsis patients hospitalized in the Intensive care unit (ICU) of the Nankai Hospital. All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.

Full description

All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Males or females over the age of 18;
2. Sepsis was diagnosed within 48h which meets SPESIS 3 criteria;
3. Capable of understanding the purpose and risk of the study;
4. Patients or proxy must give written informed consent before any assessment is performed.

Exclusion criteria

1. Pregnancy, lactation or perinatal period;
2. Breast carcinoma;
3. HIV seropositive or Syphilis seropositive;
4. Any clinical-relevant condition that might affect study participation and/or study results;
5. Participation in any other intervention trial;
6. Unwillingness or inability to following the study protocol in the investigators opinion.

Trial design

150 participants in 2 patient groups

Sepsis

Description:

disease

Treatment:

Other: nothing

Healthy controls

Description:

healthy

Treatment:

Other: nothing