Holmium Laser Uretherotomy in Combination With Intralesional Steroids in Bulbar Uretheral Stricture

Ain Shams University

Status: Completed

Conditions: Urethral Stricture

Treatments: Procedure: Laser uretherotomy with triamcinolone; Procedure: Laser uretherotomy

Study type: Interventional

Funder types: Other

Identifiers

NCT05078788

M D 98/ 2020

Details and patient eligibility

About

the purpose is to evaluate the outcome of visual internal uretherotomy with Holmium laser along with intralesional steroid injection.

Full description

In this study, the investigator evaluates the efficacy of Holmium laser in combination with intra lesional steroid injection in the treatment of bulbar urethral strictures

Enrollment: 124 patients

Sex: Male

Ages: 26 to 69 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Presence of obstructive symptoms,
2. Short segment strictures (stricture length <2 cm) as evident on radiological studies, i.e. retrograde urethrography and micturating cystourethrography.
3. Peak flow rate on uroflowmetry less than 15 ml/s

Exclusion criteria

1. Complete obliteration of lumen of urethra on urethroscopy,
2. Balanitis Xerotica Obliterans,
3. Age less than 18 years,
4. Multiple strictures,
5. Active urinary tract infection,
6. Recurrent Strictures.
7. Prior internal uretherotomy
8. Prior urethroplasty
9. Pan-anterior urethral strictures
10. Posterior stenosis
11. Those who lost to follow up

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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124 participants in 2 patient groups

Laser uretherotomy

Experimental group

Description:

Using Holmium laser uretherotomy only in the treatment of bulbar uretheral stricture

Treatment:

Procedure: Laser uretherotomy

Laser uretherotomy with intralesional steroids

Experimental group

Description:

Using holmium laser uretherotomy with injection of 80 mg of triamcinolone (diluted with normal saline to 10 ml) in the treatment of bulbar uretheral stricture

Treatment:

Procedure: Laser uretherotomy with triamcinolone