Home-based Cognitive Monitoring in MCI

Asan Medical Center

Status: Unknown

Conditions: Mild Cognitive Impairment

Treatments: Diagnostic Test: home-based cognitive monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT04350801

Hom-based cognitive monitoring

Details and patient eligibility

About

This study is an observational study to confirm usefulness of a home-based cognitive monitoring in non-demented patients with high-risk of dementia

Full description

We prospectively enroll subjects who were diagnosed as mild cognitive impairment based on neuropsychological tests battery, brain MRI, and routine blood labs including thyroid function tests, vitamine B12 & folate levels, and syphilis screening to rule out other secondary causes of dementia. We undergo peripheral blood-based amyloid beta levels and regular home-based cognitive monitoring (every 3 months) to investigate whether amyloid-positive MCIs progress rapidly using home-based cognitive monitoring during 6 months.

Enrollment: 40 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• persistent cognitive complaints
• aged 50 years old or older
• below -1.0 standard deviation in any domain of detailed neuropsychological tests battery named SNSB (Seoul neuropsychological screening battery)
• no ADL (activities of daily living) limitation
• subjects who agreed to participate

Exclusion criteria

• dementia patients
• other structural brain disorders such as hydrocephalus, hemorrhage, or tumors
• other neurological disease such as Huntington's disease, Parkinson's disease, or epilepsy

Trial design

40 participants in 2 patient groups

high risk MCI

Description:

MCI patients with amyloid beta positive (based on peripheral blood level)

Treatment:

Diagnostic Test: home-based cognitive monitoring

low risk MCI

Description:

MCI patients with amyloid beta negative (based on peripheral blood level)

Treatment:

Diagnostic Test: home-based cognitive monitoring