Home-Based Strategies for Knee Osteoarthritis

Istanbul University - Cerrahpasa

Status: Enrolling

Conditions: Knee Osteoarthritis (Knee OA); Knee Osteoarthritis

Treatments: Other: Topical Therapy Group; Other: Home Exercise Group

Study type: Interventional

Funder types: Other

Identifiers

NCT07212647

132409382161

Details and patient eligibility

About

Knee osteoarthritis (KOA) is a common chronic joint condition leading to pain, functional limitations, and reduced quality of life. This randomized controlled trial aims to evaluate and compare the effectiveness of a structured home-based exercise program versus topical diclofenac sodium therapy in improving pain, functional outcomes, and health-related quality of life among adults with early-stage KOA. The results are intended to provide evidence on the optimal components of home-based conservative management strategies.

Enrollment: 100 estimated patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 40-70 years
• Diagnosed with Kellgren-Lawrence grade I-II knee osteoarthritis
• Ability to provide written informed consent

Exclusion criteria

• Advanced KOA (Kellgren-Lawrence grade IV) requiring arthroplasty
• Prior knee surgery within the past year
• Intra-articular injections within the last 3 months
• Neurological, rheumatological, or systemic conditions affecting mobility
• Inability to comply with study procedures

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Home Exercise Group

Experimental group

Description:

Each subject in the home exercise group will receive a video-based protocol of exercises for knee osteoarthritis to perform at home.

Treatment:

Other: Home Exercise Group

Topical Therapy Group

Active Comparator group

Description:

Each subject in the topical therapy group will apply topical gel to anterior, medial, and lateral aspects of the knee at home.

Treatment:

Other: Topical Therapy Group