Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

The University of Texas System (UT)

Status

Enrolling

Conditions

Huntington Disease

Treatments

Device: active tDCS

Study type

Interventional

Funder types

Other

Identifiers

NCT05326451

HSC-MS-21-1065

Details and patient eligibility

About

The purpose of this study is to assess feasibility, acceptability, and safety of providing transcranial direct current stimulation( tDCS) to Huntingtons Disease (HD) patients in the early to middle stages and to assess the efficacy of tDCS for HD-related behavioral, cognitive and other symptoms

Enrollment

10 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Participant:

Inclusion Criteria:

confirmed HD mutation carriers and/or established family history alongside typical symptoms (i.e. chorea) of HD;
early (stages 1 and 2) or moderate (stage 3) stages according to Shoulson-Fahn
exhibit mild to moderate behavioral symptoms defined by severity scores in the PBA-S between 1 and 3 for any of the evaluated symptoms and no symptoms with a severity score of 4
stable doses of medications for at least one month
Have a caregiver willing to be present during tDCS sessions and answer questionnaires.

Exclusion Criteria:

unstable medical conditions
history of epilepsy
metallic objects in the brain
Have a caregiver willing to be present during tDCS sessions and answer questionnaires.
clinical diagnosis of major cognitive disorder or dementia
Have risk of suicidal behavior, defined as any suicidal behavior or suicidal ideation of type 4 or type 5 based on the Columbia-Suicide Severity Rating Scale (C-SSRS) in the 3 months prior to screening
simultaneous participation in other clinical trial
Individuals determined to be incapable of consent per past medical history or via assessment by the study staff at time of consent.

Caregiver:

Inclusion Criteria:

-willingness to participate in the study

Exclusion Criteria:

-motor/cognitive symptoms related to Alzheimer's disease or Huntington's disease that might impair the ability to assist the participant during the research study.