Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

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The University of Texas System (UT)

Status

Enrolling

Conditions

Huntington Disease

Treatments

Device: active tDCS

Study type

Interventional

Funder types

Other

Identifiers

NCT05326451
HSC-MS-21-1065

Details and patient eligibility

About

The purpose of this study is to assess feasibility, acceptability, and safety of providing transcranial direct current stimulation( tDCS) to Huntingtons Disease (HD) patients in the early to middle stages and to assess the efficacy of tDCS for HD-related behavioral, cognitive and other symptoms

Enrollment

10 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Participant:

Inclusion Criteria:

  • confirmed HD mutation carriers
  • early (stages 1 and 2) or moderate (stage 3) stages according to Shoulson-Fahn
  • exhibit mild to moderate behavioral symptoms, such as clinically diagnosed apathy, irritability, anxiety, depression, aggression and repetition
  • stable doses of medications for at least one month

Exclusion Criteria:

  • unstable medical conditions
  • history of epilepsy
  • metallic objects in the brain
  • clinical diagnosis of major cognitive disorder or dementia
  • Have risk of suicidal behavior, defined as any suicidal behavior or suicidal ideation of type 4

Caregiver:

Inclusion Criteria:

-willingness to participate in the study

Exclusion Criteria:

-motor/cognitive symptoms related to Alzheimer's disease or Huntington's disease that might impair the ability to assist the participant during the research study.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

active tDCS
Experimental group
Treatment:
Device: active tDCS

Trial contacts and locations

1

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Central trial contact

Thiago Macedo e Cordeiro, MD; Erin Stimming, MD

Data sourced from clinicaltrials.gov

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