Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

The University of Texas System (UT)

Status: Enrolling

Conditions: Huntington Disease

Treatments: Device: active tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT05326451

HSC-MS-21-1065

Details and patient eligibility

About

The purpose of this study is to assess feasibility, acceptability, and safety of providing transcranial direct current stimulation( tDCS) to Huntingtons Disease (HD) patients in the early to middle stages and to assess the efficacy of tDCS for HD-related behavioral, cognitive and other symptoms

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Participant:

Inclusion Criteria:

• confirmed HD mutation carriers
• early (stages 1 and 2) or moderate (stage 3) stages according to Shoulson-Fahn
• exhibit mild to moderate behavioral symptoms, such as clinically diagnosed apathy, irritability, anxiety, depression, aggression and repetition
• stable doses of medications for at least one month

Exclusion Criteria:

• unstable medical conditions
• history of epilepsy
• metallic objects in the brain
• clinical diagnosis of major cognitive disorder or dementia
• Have risk of suicidal behavior, defined as any suicidal behavior or suicidal ideation of type 4

Caregiver:

Inclusion Criteria:

-willingness to participate in the study

Exclusion Criteria:

-motor/cognitive symptoms related to Alzheimer's disease or Huntington's disease that might impair the ability to assist the participant during the research study.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

active tDCS

Experimental group

Treatment:

Device: active tDCS