Home-based Transcranial Direct Current Stimulation for Pain Management in Persons With Alzheimer's Disease and Related Dementias
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Details and patient eligibility
About
The purpose of this project is to evaluate the preliminary effects of home-based M1-SO applied tDCS (that is, tDCS with the anode over the primary motor cortex and the cathode over the contralateral supraorbital area) on clinical pain in persons with early-stage Alzheimer's disease and Related Dementias (ADRD), to evaluate the preliminary effects of home-based M1-SO applied tDCS on pain-related cortical response in persons with early-stage ADRD, and to evaluate the feasibility and acceptability of home-based M1-SO applied tDCS for pain management in persons with early-stage AD.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- early-stage Alzhimer's disease and related dementias (ADRD)
- have caregiver-reported chronic pain (average pain in the past 3 months ≥ 3 out of 10),
- have a caregiver willing to participate in the study who sees the participant at least 10 hours/week
- can speak and read English
- have no plans to change medication regimens during the trial
Exclusion criteria
- history of brain surgery, brain tumor, seizure, stroke, or intracranial metal implantation
- alcohol/substance abuse
- severely diminished cognitive function (i.e., MiniMental Status Exam score ≤ 15)
- hospitalization within the preceding year for neuropsychiatric illness
Trial design
Primary purpose
Allocation
Interventional model
Masking
40 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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