Homeostatic Roles of Eosinophils in Asthma (HOMEOS)

Centre Hospitalier Universitaire de Besancon

Status: Not yet enrolling

Conditions: Asthma; Eosinophilic

Treatments: Procedure: Blood Punction

Study type: Interventional

Funder types: Other

Identifiers

NCT06676397

2024/877

Details and patient eligibility

About

The HOMEOS study is an exploratory, observational, and monocentric research. It focuses on characterizing the homeostatic roles of eosinophils in severe asthma. The primary objective is to identify eosinophil subpopulations among different groups of severe asthmatic patients using flow cytometry. The study aims to advance understanding of eosinophil diversity, which could guide new therapeutic approaches .

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients diagnosed with mild asthma with severe asthma (Biologic-naïve, responders to anti-eosinophil biologic therapies and resistant to anti-eosinophil biologic therapies), control subjects without asthma
• Signature of informed consent
• Affiliation with the French social security system

Exclusion criteria

• Non-eosinophilic asthma
• Coexistence of a chronic eosinophilic inflammatory condition other than asthma
• Other respiratory conditions (cystic fibrosis, COPD, allergic bronchopulmonary aspergillosis, etc.)
• Treatment with corticosteroids within 10 days prior to inclusion
• Active smoking or a smoking history of more than 20 pack-years
• Pregnant women
• Legal incapacity or limited legal capacity
• Subject unlikely to cooperate with the study and/or with anticipated low cooperation as assessed by the investigator
• Subject without health insurance
• Subject currently in an exclusion period of another study or as indicated by the "national registry of volunteers."

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 5 patient groups

Severe Asthma Patients : Biologic Naïves

Other group

Description:

Severe Asthma Patients : Biologic Naïves

Treatment:

Procedure: Blood Punction

Severe Asthma Patients: Responders to Biologics

Other group

Description:

Severe Asthma Patients: Responders to Biologics

Treatment:

Procedure: Blood Punction

Severe Asthma Patients: Non Responders to Biologics

Other group

Description:

Severe Asthma Patients: Non Responders to Biologics

Treatment:

Procedure: Blood Punction

Mild asthmatics

Other group

Description:

Mild asthmatics

Treatment:

Procedure: Blood Punction

Healthy Controls

Other group

Description:

Healthy Controls

Treatment:

Procedure: Blood Punction