Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality

The Chinese University of Hong Kong

Status: Completed

Conditions: Aging; Cognitive Decline; Sleep Disturbance; Brain Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06170073

2023.496

Details and patient eligibility

About

Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.

Full description

Objectives: This study aims to investigate the cognitive changes in older adults with sleep disturbances, examine the neuroimaging contributors to poor sleep quality and cognitive deficits.

Enrollment: 238 patients

Sex: All

Ages: 55 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Chinese old adults are the ones who are over 60 years of chronological age.
• Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score >5.

Exclusion criteria

• History of bipolar disorders or psychosis.
• History of major neurological deficits, including stroke, transient ischemic attack or brain tumor.
• Unable to participant magnetic resonance imaging (MRI) scanning.

Trial design

238 participants in 2 patient groups

Poor sleepers

Description:

With a total score of Pittsburgh Sleep Quality Index (PSQI) \> 5.

Good sleepers

Description:

With a total score of Pittsburgh Sleep Quality Index (PSQI) ≤ 5.