Hookworm Immune Regulation Project (HIRP-01)

CHU Brugmann University Hospital

Status: Unknown

Conditions: Hookworm Infection

Treatments: Other: Blood and feces sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT02262403

CHUB-HIRP-01

Details and patient eligibility

About

The main objective of this study is to characterize the regulatory immune response induced by hookworm in an infected Vietnamese rural population from the periphery of HCM, evolution after infection treatment and during potential naturally reinfection.

Full description

Population: 20 healthy adults (18-65 years) infected and non infected by Hookworm will be recruited and treated according to Good Clinical Practice recommendations.

Allergy will be excluded by skin prick tests. Amount and phenotype of Treg will be explored at several time points. Subsequent culture with environmental antigen will be performed on cryopreserved cells.

Enrollment: 40 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-65 years old adults in good health status
• To live in rural regions at risk of soil transmitted helminthes
• Hookworm infection (infected group)
• Uninfected by Hookworms (control group)

Exclusion criteria

• Pregnant woman
• Positive allergic history
• Auto-immune and/or HIV disease
• Antihelminthics drug in the last 6 months and other current parasitic infection

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Hookworm infected

Experimental group

Description:

The amount, phenotype and function of Treg will be explored at several time points. Cultures with environmental antigen will be subsequently performed.

Treatment:

Other: Blood and feces sampling

Non infected (hookworms) healthy subjects

Active Comparator group

Description:

All the tests done in the experimental hookworm infected group will be also done in the comparator non infected group.

Treatment:

Other: Blood and feces sampling