Hop Compounds and Immune System (HI)

University of Vienna

Status: Completed

Conditions: Inflammatory Response

Treatments: Other: Dietary Intervention 1: Placebo; Other: Dietary Intervention 2: Xanthohumol and Iso-alpha acids

Study type: Interventional

Funder types: Other

Identifiers

NCT04847193

UVienna19a

Details and patient eligibility

About

The aim of the present study is to determine the effect of Xanthohumol and Iso-alpha-acids from hops on the immune response of healthy participants.

Full description

In this placebo-controlled crossover study a study drink enriched with either a placebo, Xanthohumol, Iso-alpha Acids or a combination of latter is given to the participants. A washout phase before intervention and between each intervention is introduced. On day one of each intervention blood is drawn in fasted state from each participant. Subsequently the study drink combined with a standardized breakfast is given to the participants following a second blood drawing one hour after the consumption of the study drink. On the last day of each intervention blood is taken from study participants in the same manner as on day one. To assess the effect of Xanthohumol and Iso-alpha acids or a combination of both, clinical chemical parameters e.g. ALT, AST, γ-GT, blood lipids (triglycerides, total cholesterol, HDL, LDL), blood glucose, uric acid and CRP are determined. Furthermore, PBMC's isolated from blood samples of each time point were stimulated for either 24 or 48 h. Protein levels and mRNA expression of markers of inflammation is measured in PBMC's and supernatant of stimulated cells.

Enrollment: 15 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy, normal weight,

Exclusion criteria

• food intolerances, food allergies, chronic inflammatory diseases, metabolic diseases, viral or bacterial infections within the last 3 weeks of inclusion, intake of immunosupressive medication

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

15 participants in 4 patient groups

Placebo

Experimental group

Description:

Participants receive a study drink supplemented with a placebo over a time period of 5 days.

Treatment:

Other: Dietary Intervention 1: Placebo

Xanthohumol

Experimental group

Description:

Participants receive a study drink supplemented with Xanthohumol over a time period of 5 days.

Treatment:

Other: Dietary Intervention 2: Xanthohumol and Iso-alpha acids

Iso-alpha acids

Experimental group

Description:

Participants receive a study drink supplemented with Iso-alpha acids over a time period of 5 days.

Treatment:

Other: Dietary Intervention 2: Xanthohumol and Iso-alpha acids

Xanthohumol/Iso-alpha acids

Experimental group

Description:

Participants receive a study drink supplemented with a combination of Xanthohumol and Iso-alpha acids over a time period of 5 days.

Treatment:

Other: Dietary Intervention 2: Xanthohumol and Iso-alpha acids