Hop Compounds on the Immune System (VH)

University of Vienna

Status: Enrolling

Conditions: Inflammatory Response

Treatments: Dietary Supplement: Xanthohumol + Iso-alpha-Acids; Dietary Supplement: Xanthohumol; Dietary Supplement: Iso-alpha-Acids

Study type: Interventional

Funder types: Other

Identifiers

NCT06286644

UVienna23

Details and patient eligibility

About

The aim of the present study is to determine the effect of Iso-alpha-Acids and Xanthohumol from hops on the immune response of healthy participants over a timeframe of 6 hours.

Full description

In this placebo-controlled crossover study a study drink enriched with either a placebo, Xanthohumol, Iso-alpha Acids or a combination of latter is given to the participants. A washout phase before intervention and between each intervention is introduced. On day one of each intervention blood is drawn in fasted state from each participant. Subsequently the study drink combined with a standardized breakfast is given to the participants followed by blood draws 1, 2, 3, 4 and 6 hours after the consumption of the study drink. To assess the effect of Xanthohumol and Iso-alpha acids or a combination of both, clinical parameters, blood lipids, blood glucose, uric acid and inflammatory markers will be determined. Furthermore, blood cells, isolated from blood samples of each time point, will be stimulated for measuring inflammatory markers.

Enrollment: 14 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy
• BMI: >18,5 kg/m² or <30 kg/m²

Exclusion criteria

• food intolerances
• food allergies
• chronic inflammatory diseases
• metabolic diseases
• viral or bacterial infections within the last 3 weeks of inclusion
• intake of immunosuppressive medication

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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14 participants in 3 patient groups

Xanthohumol

Experimental group

Description:

Participants receive a study drink supplemented with Xanthohumol (0mg = Placebo; 0,125 mg; 0,375 mg or 0,75 mg soluble Xanthohumol)

Treatment:

Dietary Supplement: Xanthohumol

Iso-alpha-Acids

Experimental group

Description:

Participants receive a study drink supplemented with Xanthohumol (0 mg = Placebo; 15 mg, 45 mg or 90 mg Iso-alpha-Acids)

Treatment:

Dietary Supplement: Iso-alpha-Acids

Xanthohumol/Iso-alpha-Acids

Experimental group

Description:

Participants receive a study drink supplemented with Xanthohumol + Iso-alpha-Acids (0 mg = Placebo; 0,125 mg + 15 mg, 0,375 mg + 45 mg or 0,75 mg + 90 mg soluble Xanthohumol + Iso-alpha-Acids)

Treatment:

Dietary Supplement: Xanthohumol + Iso-alpha-Acids