Hormonal and Metabolic Consequences of Sleep Disorders in Young Obese Patients (SOM)

C

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status

Unknown

Conditions

Sleep Disorders
Obesity

Study type

Observational

Funder types

Other

Identifiers

NCT00716222
B40320084032

Details and patient eligibility

About

There is a well-documented relationship between short sleep duration and high body mass index (BMI). The mechanism linking short sleep duration and weight gain is unknown. Current studies in healthy young volunteers have shown that experimental sleep restriction is associated with dysregulation of the neuroendocrine control of appetite and with alterations in glucose metabolism. The goal of our study is to determine the metabolic and hormonal modifications induced by chronic sleep curtailment in obese adolescents and young adults and to observe if short sleep is a negative prognostic factor in their weight evolution.

Full description

The main purpose of the study is investigate whether the concentrations of 2 hormones that regulate appetite (leptin, ghrelin), cytokines (TNF-a, IL-6) and CRP are modified in obese adolescents and young adults who had sleep disorders in comparison to obese adolescents and young adults who sleep longer.

Enrollment

70 estimated patients

Sex

All

Ages

13 to 25 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 13-25 years old
  • BMI > 30 kg/m2 (If adolescents aged under 18 years: BMI equivalent to a BMI for age and sex to a BMI of 30, according to the Cole et al. obesity criteria).

Exclusion criteria

  • Infection
  • Liver disease
  • Chronic inflammatory disease
  • Endocrine disease
  • Use of drugs that alter the sensitivity of insulin

Trial design

70 participants in 3 patient groups

1
Description:
Obese adolescent and young adult with sleep disorder
2
Description:
Obese adolescent and young adult without sleep disorder
3
Description:
Lean adolescent and young adult with sleep disorder

Trial contacts and locations

0

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Central trial contact

Veronique VB Beauloye, PhD

Data sourced from clinicaltrials.gov

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