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Hormones and Decision Making

The University of Texas System (UT) logo

The University of Texas System (UT)

Status and phase

Completed
Phase 4

Conditions

Dyssocial Behavior

Treatments

Drug: testosterone propionate
Drug: 0.5% cholorbutanol, saline

Study type

Interventional

Funder types

Other

Identifiers

NCT04865562
2015-02-0011

Details and patient eligibility

About

An investigation of the neuropsychological processes underlying ethical decision making.

Full description

This study will investigate the influence of reward sensitivity on cheating behavior via experimental manipulation of reward sensitivity using testosterone.

Enrollment

30 patients

Sex

Male

Ages

18 to 25 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • males between 18 and 25

Exclusion criteria

  • recruitment will be limited to male participants between 18 and 25 years who have no current conditions that would preclude the use of testosterone. Specific exclusion criteria are:
  • women of all ages
  • males younger than 18 years and older than 25 years
  • self-report discomfort with ingestion of testosterone for the purpose of this study
  • body mass index lower than 18 or higher than 27
  • prior diagnosis of major depression, posttraumatic stress disorder, phobia, anxiety disorder, or other psychiatric conditions
  • first-degree relatives diagnosed with a psychiatric disorder
  • presence of a medical condition that would preclude the use of testosterone
  • use of medications that would preclude the use of testosterone
  • consumption of more than 5 cigarettes a day
  • current use of testosterone enhancing products, such as gels, creams, and injections

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

30 participants in 2 patient groups, including a placebo group

testosterone
Experimental group
Description:
7mg testosterone propionate
Treatment:
Drug: testosterone propionate
placebo
Placebo Comparator group
Description:
125 mg 0.5% cholorbutanol, 50mg saline, pH5
Treatment:
Drug: 0.5% cholorbutanol, saline

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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