Host Dysregulation-Driven Sepsis Prediction Model

Second Affiliated Hospital of Wenzhou Medical University

Status: Completed

Conditions: Sepsis

Treatments: Other: Interleukin-18; Other: Tumor Necrosis Factor; Other: Complement C5; Other: Interleukin-1β; Other: Interleukin-12; Other: Complement C3

Study type: Observational

Funder types: Other

Identifiers

NCT06523075

SAHoWMU-CR2024-16-214

Details and patient eligibility

About

The aim of this study is to identify risk factors associated with sepsis and to construct a predictive model for sepsis. This will provide an objective theoretical and empirical foundation for the diagnosis, assessment, and management of sepsis in our country.The primary questions addressed are:

What are the risk factors for the development of sepsis? How do we improve the prognosis of sepsis?

Enrollment: 1,000 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with Infection or Suspected Infection

Exclusion criteria

• Patients with Autoimmune Diseases
• Pregnant Women
• Patients with Advanced-Stage Cancer and Systemic Metastasis

Trial design

1,000 participants in 2 patient groups

Sepsis Group

Treatment:

Other: Complement C3

Other: Interleukin-12

Other: Interleukin-1β

Other: Complement C5

Other: Tumor Necrosis Factor

Other: Interleukin-18

Non-Sepsis Group

Treatment:

Other: Complement C3

Other: Interleukin-12

Other: Interleukin-1β

Other: Complement C5

Other: Tumor Necrosis Factor

Other: Interleukin-18