Host Response to Urinary Tract Infection in Women

University of Washington

Status: Completed

Conditions: Urinary Tract Infection

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00642070

31467-D

NIDDK 1 P50 AR049475-06 ;

06-4836-D (Other Identifier)

Details and patient eligibility

About

This study is being done to identify those elements of the immune response that may predispose a woman to recurrent urinary tract infection. We suspect that lesser effectiveness of certain components of the host response will lead to recurrent urinary tract infection. We will also evaluate the role that the bladder reservoir may play in recurrent urinary tract infection.

Full description

Procedures subjects will undergo once they have read and signed the consent are:

Questions about their medical and sexual history and current symptoms of urinary tract infection. They will be asked to provide a clean catch urine sample. We will collect periurethral, vaginal and rectal swabs. Blood will collected. They will be given a diary to take home and record all episodes of sexual intercourse, contraceptive use, vaginal and urinary symptoms and medication use.

They will be given standard treatment for the current urinary tract infection. Follow-up visits will be scheduled 2 weeks,one month,two month and three month after initial visit.

Enrollment: 326 patients

Sex: Female

Ages: 18 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female
• Age 18-49 years
• Able to provide written informed consent
• diagnosis of acute cystitis with symptoms for fewer than 7 days

Exclusion criteria

• Not pregnant or planning pregnancy in next 3 months
• No chronic illness requiring medical supervision (e.g. diabetes mellitus)
• No known anatomic or functional abnormalities of the urinary tract
• No signs or symptoms suggestive of pyelonephritis (flank pain or tenderness, temperature over 100 degrees F, nausea or vomiting)

Trial design

326 participants in 1 patient group

Host

Description:

Women with current symptoms of a urinary tract infection