Hot Flashes and Neurovascular Function in Women

Mayo Clinic

Status: Enrolling

Conditions: Menopause; Hot Flashes; Vasomotor System; Labile

Treatments: Drug: Sodium Nitroprusside; Drug: Norepinephrine; Other: Sympathoexcitatory stressors; Drug: Acetylcholine; Drug: Terbutaline

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05193968

K01HL148144 (U.S. NIH Grant/Contract)

19-002638

Details and patient eligibility

About

Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between hot flashes and neurovascular dysfunction and, by extension, cardiovascular disease in women.

Enrollment: 120 estimated patients

Sex: Female

Ages: 40 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-smokers.
• Non-obese.
• Have at least one ovary.
• Free from cardiovascular disease.
• Not taking medications influencing cardiovascular function.

Exclusion criteria

• None.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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120 participants in 1 patient group

Experimental: Healthy Women Volunteers

Other group

Description:

Hot Flash frequency will be assessed in the study subjects during a screening period. Participants can then chose to participate 1 or 2 study visits- Protocol 1: Microvascular function and/or Protocol 2: Autonomic function

Treatment:

Drug: Terbutaline

Drug: Acetylcholine

Other: Sympathoexcitatory stressors

Drug: Norepinephrine

Drug: Sodium Nitroprusside