Associations of Nighttime Light Exposure During Pregnancy With Neonatal Jaundice：a Multi-centre Prospective Study in China (jaundice)

Guangdong Women and Children Hospital

Status: Completed

Conditions: Jaundice, Neonatal

Study type: Observational

Funder types: Other

Identifiers

NCT03805165

Guangdong WCH

Details and patient eligibility

About

Make a neonatal jaundiced nomogram on Chinese jaundice data by joinning the major neonate centers all around China.

Full description

This was a multi-centre prospective study. All infants included were born in 8 hospitals in the southern, eastern, northern, western and central regions of mainland China in 2019. A total of 20839 transcutaneous bilirubin(TCB) measurements were performed with 2977 neonates at designated time points. The mean NTL exposure during pregnancy was respectively calculated based on each participant's residential address over the study course. The primary outcome was whether the neonate was diagnosed with hyperbilirubinemia within the first seven days of life. The effect of maternal nocturnal light exposure on neonate jaundice analyzed with lasso regression and random forest machine learning methods.

Enrollment: 2,977 patients

Sex: All

Ages: 1 to 7 days old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

gestational age more than 35 weeks(≥35) -

Exclusion criteria

all kinds of congenital diseases, infants with pathologic jaundice

Trial design

2,977 participants in 1 patient group

neonate

Description:

transcutaneous bilirubin(TCB) measurements were performed with 2977 neonates at designated time points. The mean NTL exposure during pregnancy was respectively calculated based on each participant's residential address over the study course.