House Dust Mite Induced Inflammasome Activation on Corticosteroid Resistance

China Medical University

Status: Withdrawn

Conditions: Allergic Asthma

Treatments: Biological: House dust mite

Study type: Interventional

Funder types: Other

Identifiers

NCT03307278

CMUH106-REC3-115

Details and patient eligibility

About

In this project, PBMCs will be isolated from HDM allergic and non allergic patient and then stimulated with HDM crude extract. The expression of inflammasome and the correlation of inflammasome activation and steroid resistance will be investigated.

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• HDM allergic and non allergic subjects

Exclusion criteria

• Pregnant subject, cancer

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Steroid resistance in HDM allergic patients

Experimental group

Treatment:

Biological: House dust mite

Steroid resistance in non HDM allergic subjects

Experimental group

Treatment:

Biological: House dust mite