How Does 4 Weeks of Increased Fast Food Intake Affect Metabolism?

University Hospital, Linkoeping

Status: Completed

Conditions: Healthy; Hyper-Alimentation

Treatments: Procedure: Fast food arm

Study type: Interventional

Funder types: Other

Identifiers

NCT00826631

M158-05

Details and patient eligibility

About

Objective: To study the effect of fast food-based hyper-alimentation on liver enzymes and hepatic triglyceride content (HTGC)and metabolism.

Design: Prospective interventional study with parallel control group. Setting University Hospital of Linköping, Sweden. Participants: 12 healthy men and six healthy women with a mean (SD) age of 26 (6.6) years and a matched control group.

Intervention: Subjects in the intervention group aimed for a body weight increase of 5-15% by eating at least two fast food-based meals a day with the goal to double the regular caloric intake in combination with adoption of a sedentary lifestyle for four weeks.

Main outcome measures: Weekly changes of serum aminotransferases and HTGC measured by proton nuclear magnetic resonance-spectroscopy at baseline and after the intervention.

Enrollment: 36 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy non-obese subjects

Exclusion criteria

• General diseases, obesity.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

1

Active Comparator group

Description:

Fast food intake, doubling of caloric intake, in combination with sedentary behavior (no exercise)

Treatment:

Procedure: Fast food arm

2

No Intervention group

Description:

Control group, parallel