How Does Prostate Cancer Metastasize? Studying the Role of Secreted Packages (Exosomes) From Fat Tissue in Lean and Obese Patients (EXOPRO)

Imperial College London

Status: Enrolling

Conditions: Obesity; Prostate Cancer

Treatments: Procedure: Robotic Radical Prostatectomy

Study type: Observational

Funder types: Other

Identifiers

NCT04167722

19HH5065

Details and patient eligibility

About

The investigators will be collecting prostate and fat tissue from participants undergoing radical prostatectomy to culture and study in the laboratory.

Full description

Both obesity and prostate cancer are major health problems in the UK, affecting 1 in 3 and 1 in 8 men respectively. Moreover, obesity increases the risk of developing aggressive disease and the risk of prostate cancer spreading. How this happens is not known. The investigators want to understand how fat cells communicate with prostate cancer cells. Investigators will be collecting prostate and fat tissue from radical prostatectomy participants for culture, in particular to look at exosome communication.

Enrollment: 100 estimated patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

• All men undergoing radical prostatectomy at Charing Cross Hospital

Exclusion criteria

• Patients unable to consent

Trial design

100 participants in 2 patient groups

Obese patients

Description:

BMI \> 25

Treatment:

Procedure: Robotic Radical Prostatectomy

Lean patients

Description:

BMI \< or = 25

Treatment:

Procedure: Robotic Radical Prostatectomy