How Menopause Affects Lipid Metabolism in the Visceral Fat Depots

Rigshospitalet

Status: Unknown

Conditions: Insulin Sensitivity and Lipid Metabolism

Treatments: Other: This is an observational study. There are no interventions

Study type: Observational

Funder types: Other

Identifiers

NCT02524457

H-3-2014-096

Details and patient eligibility

About

The purpose of the study is to describe the molecular mechanisms related to an increased visceral fat mass and changed T-cell homeostasis. the project is expected to add new knowledge to the field of metabolic diseases after menopause and increase the focus of how lipid affects the development of metabolic disease in relation to the menopausal transition.

Full description

The study is a cross sectional study including 60 women between 45 and 55 years of age. Investigators aim to include 20 premenopausal women, 20 postmenopausal women and 20 postmenopausal women taking hormone treatment (HT). All the women are going through gynecological surgery for benign reasons. During the operation investigators will take a visceral fat biopsy from the omentum.

maximally 1 month before- or after the operation the subject will meet at the lab for further testing, including:

• Health examination
• Blood samples
• OGTT
• DXA scan
• VO2 max testing
• MRI of the abdomen
• hyperinsulinemic euglycemic clamp

Enrollment: 60 estimated patients

Sex: Female

Ages: 45 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women
• 45-55 years old
• for HT treated women (HT more than 1 year)

Exclusion criteria

• Infections during the last month
• chronic disease
• claustrophobia
• smoking
• Alcoholic intake > 14 servings
• hysterectomy before menopause
• oophorectomized
• early menopause (before 40 yrs)
• BMI > 30

Trial design

60 participants in 3 patient groups

Premenopausal

Description:

Premenopausal women going through gynecological surgery

Treatment:

Other: This is an observational study. There are no interventions

Postmenopausal

Description:

Postemnopausal women going through gynecological surgery

Treatment:

Other: This is an observational study. There are no interventions

Postmenopausal + HT

Description:

Postmenopausal women going through gynecological surgery who has been taking hormone treatment through the past year (as a minimum)

Treatment:

Other: This is an observational study. There are no interventions