How Orally Consumed 3-hydroxybuturate Alters Metabolism

University of Aarhus

Status: Completed

Conditions: Acute Ketosis

Treatments: Other: Placebo; Other: 3-hydroxybuturate

Study type: Interventional

Funder types: Other

Identifiers

NCT02917252

RM-1-10-72-157-16

Details and patient eligibility

About

This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.

Full description

Subject participate for two separate days; i) intervention, ii) placebo. Intervention: subjects drink ketone body solution. Tracer kinetics on glucose and lipid metabolism is applied. Muscle tissue and adipose tissue biopsies are taken.

Placebo: subjects drink saline. Same sampling as on intervention day.

Enrollment: 6 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 20-30

Exclusion criteria

• Smoking
• alcohol or drug abuse
• Critically ill

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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6 participants in 2 patient groups, including a placebo group

Intervention

Active Comparator group

Description:

Subjects drink 3-hydroxybuturate

Treatment:

Other: 3-hydroxybuturate

Placebo

Placebo Comparator group

Description:

Subjects drink saline

Treatment:

Other: Placebo