How to Improve Diagnosis in Infective Endocarditis

University of Aarhus

Status

Completed

Conditions

Endocarditis, Bacterial

Study type

Observational

Funder types

Other

Identifiers

NCT00524212

06-10-B640-A1205-22345

20060181

SUN-2007-653

Details and patient eligibility

About

The purpose is to exam prospective if simple clinical information in combination with a normal s-procalcitonin are sufficient for exclusion of infective endocarditis (IE).

Full description

Despite progress in surgical and medical treatment, infective endocarditis is still associated with high morbidity and mortality.

The variable clinical presentation of IE makes the diagnosis a clinical challenge.

Procalcitonin is a precursor from the hormone calcitonin and also a marker of systemic bacterial infections.

The purpose of this study is:

to investigate the diagnostic value of serum procalcitonin (PCT), C-reactive protein (CRP) and sedimentation rate (SR) when IE is suspected.
to investigate if a retrospectively generated clinical model suitable for exclusion of IE can be confirmed prospectively.

Enrollment

761 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria