How to Reduce Unnecessary Blood Cultures: Construction and Validation of a Predictive Score for Blood Culture Positivity in Intensive Care (PROBIty)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Infection, Fungal; Bacteremia; Infection, Bacterial

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05686577

DR200089 (PROBIty)

Details and patient eligibility

About

Prospective observational cohort consisting of all adult patients admitted to participating critical care units (ICU and CCU) during the study period, with blood cultures collected as part of their care, and who did not express any objection to participating.

For each patient, data will be collected prospectively for each blood culture set collected.

Enrollment: 2,411 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female, age 18 years or older
• Patient admitted to an ICU or ICU
• patient with a blood culture sample as part of care

Exclusion criteria

• Patient already included in this study during a previous hospitalisation
• Opposition expressed for participation in the study

Trial design

2,411 participants in 2 patient groups

learning database group

Description:

The results of blood cultures and the clinical elements of the patients in the first sample (1600 patients) will constitute the learning database. A supervised learning will be performed on these data in order to select a set of clinical elements allowing to define a predictive score of positive blood cultures

Treatment:

Other: no intervention

validation database group

Description:

The score will be validated on the remaining sample (800 patients), independent of the first sample. Both samples will be constituted by randomization.

Treatment:

Other: no intervention