HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis (HOGWARTS)

University of Modena and Reggio Emilia

Status: Enrolling

Conditions: Fibrosis, Pulmonary

Treatments: Procedure: Biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT07373288

UModenaReggio20

Details and patient eligibility

About

This pilot, multicenter, interventional study investigates the expression of HOXB7 and its associated molecular pathway in lung tissue and blood-derived exosomes from patients with pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF). Using RNA sequencing (RNA-Seq) and proteomic analysis via mass spectrometry (MS), the study aims to identify tissue and circulating biomarkers associated with fibrosis progression. The study compares different biopsy techniques (surgical vs. transbronchial cryobiopsy) and also includes a control group of patients undergoing lung resection for non-fibrotic conditions.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 18 to 80 with clinical suspicion of pulmonary fibrosis
• Availability of fresh lung tissue from biopsy or lung explant
• Signed informed consent for research use of biological material and data

Exclusion criteria

- Refusal to sign informed consent

Trial design

80 participants in 2 patient groups

Cases

Description:

Patients undergoing surgical lung biopsy/criobiopsy for clinical purpose in the diagnostic work-up of ILD.

Treatment:

Procedure: Biopsy

Controls

Description:

Patients undergoing lung lobectomy for lung cancer suspicion.

Treatment:

Procedure: Biopsy