HPV Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma

Lei Li

Status: Unknown

Conditions: Metabolome; Cervical Adenocarcinoma; Genome-wide Association Study; Transcriptome; Prognosis; Whole Exome Sequencing; Human Papillomavirus; Tumorigenesis

Treatments: Combination Product: A multi-omics analysis

Study type: Observational

Funder types: Other

Identifiers

NCT03742869

HITA

Details and patient eligibility

About

This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections. The multi-omics profiles include genome wide association study (GWAS), whole exome sequencing, analysis of transcriptomics and metabolomics. The HPV integration status is interpreted by GWAS. A comprehensive multi-omics will reveal the role of HPV integration in the molecular mechanism of tumorigenesis and prognosis of uterine cervical adenocarcinoma.

Enrollment: 40 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed primary adenocarcinoma of the uterine cervix
• Signed an approved informed consents
• Feasible for biopsy

Exclusion criteria

• Not meeting all of the inclusion criteria

Trial design

40 participants in 2 patient groups

Patients with HPV integration

Description:

The HPV integration status will be checked by GWAS.

Treatment:

Combination Product: A multi-omics analysis

Patients without HPV integration

Description:

The HPV integration status will be checked by GWAS.

Treatment:

Combination Product: A multi-omics analysis