HPV Vaccine Reminders - SEARCH II Study

Columbia University

Status: Active, not recruiting

Conditions: Human Papillomavirus Vaccination

Treatments: Behavioral: Text Message/automated phone reminder

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT06161831

AAAT1572_2

R33CA253604 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This RCT will take place at health centres and their affiliated schools and community immunization centers overseen by the Kampala Capital City Authority (KCCA) as well as at the Makerere/Mulago/Columbia Adolescent Health Clinic in Kampala. The investigators will assess the impact of vaccine text message and automated phone reminders on human papillomavirus (HPV) vaccination initiation and completion.

Full description

Cervical cancer is the leading female cancer in Uganda. HPV is the principal cause of cervical cancer. The national HPV vaccination program in Uganda includes preteen/ adolescent girls. Vaccinations are provided within schools or through community health centers. However, in Kampala, HPV vaccination especially series completion is low. While research regarding the use of text message vaccine reminders is strong in the U.S., their use has not been demonstrated in a preteen/adolescent population in Sub-Saharan Africa and other low and middle income countries (LMICs) in a full RCT. In this study, RCT caregivers of preteens/adolescents will be randomized and stratified by site, language and HPV vaccine dose needed (initiation vs. completion). Intervention families will receive text message or automated phone reminders based on family preference.

Enrollment: 396 estimated patients

Sex: Female

Ages: 10 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Be a parenting adult of an adolescent girl aged 10-14 years
• Reside in Kampala and/or the surrounding districts
• Speak English or Luganda
• Have a cell phone with text messaging capability
• Must have ability to consent

Exclusion criteria

• Parenting adult speaks other language than English or Luganda only
• Parenting adult already enrolled in the study for another child
• Participation in previous HPV vaccine reminder study

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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396 participants in 2 patient groups

Text message/automated phone reminders

Experimental group

Description:

Text message or automated phone reminders

Treatment:

Behavioral: Text Message/automated phone reminder

Usual Care

No Intervention group

Description:

No reminders