Molecules indicating endothelial injury may serve as biomarkers for severe sepsis because of the critical role of endothelial injury in organ dysfunction during severe sepsis.
HSPA12B is primarily located in endothelial cells and detectable during sepsis.
The investigators speculated that HSPA12B from endothelial cells might be correlated with severe sepsis.
Enrollment
118 patients
Sex
All
Ages
18+ years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
Adult patients
Patients meet the diagnostic criteria according to the grouping
Exclusion criteria
patients without informed consent
patients who were undergoing continuous renal replacement therapy before sampling
patients with special infection induced by virus, tubercle bacillus, mycoplasma, Chlamydia, and so on
Trial design
118 participants in 4 patient groups
sepsis
Description:
Patients with sepsis but not severe sepsis
Severe sepsis
Description:
Patients with severe sepsis
SIRS
Description:
Patients with SIRS after major orthopedics surgery