Human Anaplasmosis in Eastern France

University Hospital, Strasbourg, France

Status: Unknown

Conditions: Ehrlichia; Anaplasmosis; Tick-borne Disease

Treatments: Procedure: Blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT01013636

3960

Details and patient eligibility

About

Anaplasmosis is a tick-borne transmitted infection. Its clinical expression include fever, cytopenia and hepatitis.This infection was initially described in United States. In Europe, its epidemiology is not well known. Some isolated cases have been diagnosed in several country, were the tick Ixodes ricinus is known to transmitted another infection :the Lyme borreliosis.The purpose of our study is to look systematically for Anaplasmosis, in patient living in Eastern France, and presenting with compatible clinical symptoms using a new diagnosis tool : PCR in blood samples. So we will have new data about epidemiology in our country and the clinical symptoms that are associated with Anaplasmosis.

Enrollment: 300 estimated patients

Sex: All

Ages: 10+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient with at least one of following symptoms : fever or muscular pain or articular pain or respiratory signs or neurological signs or meningitis or erythema occurring during the three weeks after a tick bite-
• Or
• patient with fever with at least one of following criteria : thrombocytopenia, leucopenia, hepatitis, without any other cause that can explain these abnormalities.
• Or
• patient with tick-borne encephalitis, or primary stage Lyme borreliosis

Exclusion criteria

• children less that 10 years
• pregnancy
• patients with an other diagnosis that can explain clinical symptoms or biological abnormalities
• antibiotherapy with cyclins during the days before inclusion

Trial design

300 participants in 1 patient group

Anaplasma

Treatment:

Procedure: Blood sampling