Human Brown Adipose Tissue and Mitochondrial Respiration

Maastricht University Medical Centre (MUMC)

Status: Unknown

Conditions: Aging; Adipose Tissue, Brown; Obesity; Mitochondrial Metabolism Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT03111719

NL31367.068.10

Details and patient eligibility

About

This study is focused on measuring mitochondrial activity of human brown adipose tissue. During surgery, adipose tissue biopsies from white and brown adipose tissue will be collected from the deep neck area. These biopsies will be used to examine mitochondrial function via histological analysis, biochemical analysis and in vitro experiments based on precursor cells present in the biopsies.

Enrollment: 180 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Indication for surgery in the supraclavicular and neck region (more specific patients diagnosed with hyperparathyroidism, struma, benign thyroid gland tumours, implantation of a vagal neurostimulator for epilepsia and cervical neurologic disorders)
• In the thyroid gland group, euthyroid function

Exclusion criteria

• Pre-operatively diagnosed malign tumour
• Patients undergoing acute surgery because of critical illness