Human Chorionic Gonadotropin Versus Granulocyte Colony Stimulating Factor in Increasing Pregnancy Rate in ICSI

Al-Azhar University

Status: Unknown

Conditions: Fertility Disorders

Treatments: Drug: Granulocyte Colony Stimulated Factor; Drug: Human Chorionic Gonadotropins

Study type: Interventional

Funder types: Other

Identifiers

NCT04606082

Gyne_415

Details and patient eligibility

About

Intrauterine Granulocyte colony stimulating factor (GCSF) was compared with intrauterine Human Chorionic Gonadotropin (HCG) in increasing clinical pregnancy rate as a primary outcome and ultrasound imaging of gestational sac as a secondary outcome.

Full description

Two hundred females with history of recurrent implantation failure and undergoing Intracytoplasmic Sprem injection (ICSI) were randomized into two groups; the first group (100 patients) received intrauterine Granulocyte colony stimulating factor (GCSF) and the second group (100) received intrauterine Human Chorionic Gonadotropin (HCG) at ovum pick up day. The clinical pregnancy rate was evaluated as a primary outcome after 14 days and ultrasound imaging of gestational sac was evaluated as a secondary outcome after 6 weeks.

Enrollment: 200 estimated patients

Sex: Female

Ages: 30 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Females suffering from recurrent implantation failure and undergoing ICSI

Exclusion criteria

• presence of comorbidity as diabetes, hypertension, heart diseases, or endocrine disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Group 1

Experimental group

Description:

Granulocyte Colony Stimulated Factor was intrauterine injected once at ovum pick up day

Treatment:

Drug: Granulocyte Colony Stimulated Factor

Group 2

Active Comparator group

Description:

500 IU Human Chorionic Gonadotropins was injected intrauterine once at ovum pick up day

Treatment:

Drug: Human Chorionic Gonadotropins