Human Intestinal Amino Acid Absorption and the Role of a Local RAS

University Children's Hospital Basel

Status: Completed

Conditions: Renin-Angiotensin Aldosterone System (RAS)

Treatments: Other: urine collection; Other: blood draw; Other: biopsy of intestinal tissue

Study type: Observational

Funder types: Other

Identifiers

NCT04524494

EK1744 ks20Vuille;

Details and patient eligibility

About

This study is to find out what role a local intestinal RAS (renin angiotensin system) plays in the context of amino acid absorption in the human intestinal tract and how this RAS and thus the amino acid absorption is influenced by the RAS-active drugs (angiotensin II AT1 receptor blockers (sartans) or ACE inhibitors).

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body Mass Index (BMI): 18-35 kg/m2
• cohort 1: therapy with an angiotensin II AT1 antagonist or ACE Inhibitor
• cohort 2: no therapy with an angiotensin II AT1 antagonist or ACE Inhibitor
• Carrying out a diagnostic gastroscopy, colonoscopy or a combined gastroscopy / colonoscopy
• Existence of written consent after detailed information about the study

Exclusion criteria

• Severe pathological changes in the gastrointestinal tract (e.g. sprue, stomach ulcers, malignancies); (reflux esophagitis and gastritis are not Exclusion criteria)
• History of gastrointestinal tract surgery (except for appendectomy and inguinal hernia surgery)
• History of malignancy
• Severe acute and chronic organ diseases requiring treatment (e.g. kidney replacement therapy)
• Patients with an increased risk of bleeding (e.g. oral anticoagulation, coagulation disorders)
• Drug or alcohol abuse
• Mental impairment limiting the ability to meet all study requirements

Trial design

50 participants in 2 patient groups

RAS- active medication

Description:

Patients taking RAS- active medication (ACE- Inhibitor, Angiotensin II AT1 Antagonist (Sartan)) on a daily Basis for at least 6 months for medical reasons

Treatment:

Other: biopsy of intestinal tissue

Other: urine collection

Other: blood draw

no RAS- active medication

Description:

Patients not taking RAS- active medication

Treatment:

Other: biopsy of intestinal tissue

Other: urine collection

Other: blood draw