Human Oral Detection of Glucose Olygomers

Oregon State University (OSU)

Status and phase: Completed; Phase 4

Conditions: Healthy Volunteers

Treatments: Drug: Acarbose

Study type: Interventional

Funder types: Other

Identifiers

NCT02589353

IRB # 5373

Details and patient eligibility

About

Although salivary contents play a major role in the early stage of food digestion process, their role in taste perception of glucose polymers is essentially unknown. It is hypothesized that the differences in salivary contents, more specifically salivary amylase concentration and activity, influence taste perception of glucose polymers and ultimately eating behavior, which is related to risks in various diseases. The current project will investigate the variation in salivary contents across individuals and its role in taste perception of glucose polymers.

Enrollment: 157 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• self-reported healthy adults between the ages of 18-60 who are fluent in English.

Exclusion criteria

• adults 61 years old and above
• smokers
• pregnant women
• taking any prescription pain/ insulin medication
• has a history of taste or smell loss or other oral disorders (e.g., burning mouth syndrome)
• has current oral lesions, canker sores, or piercings
• has a history of food allergy

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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157 participants in 1 patient group

Acarbose

Experimental group

Description:

Acarbose solution will be swabbed on the tip of the tongue to inhibit salivary alpha amylase activity; each swab will contain \~484 microgram acarbose; total maximum exposure of each subject to acarbose will be \~14-30 mg each session (1-20 sessions)

Treatment:

Drug: Acarbose