Human Single Neuron Recordings in Epilepsy Patients

University of Birmingham

Status: Unknown

Conditions: Epilepsy; Memory

Treatments: Diagnostic Test: Microwire electrodes

Study type: Interventional

Funder types: Other

Identifiers

NCT04290416

RG_15-074

Details and patient eligibility

About

This study uses single neuron recordings in pre-surgical epilepsy patients to uncover the neural mechanisms underlying memory formation and retrieval. A secondary aim is to improve diagnostic tools to identify epileptogenic tissue.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Interest in participation.
• Temporal lobe epilepsy that is clinically being investigated with implantations of depth electrodes as part of the pre-surgical epilepsy monitoring.
• Cognitive/language skills sufficient to follow experimental instruction and maintain focus on the experiment.

Exclusion criteria

• Patient does not want to participate.
• Extra-temporal epilepsy, or electrode implantation strategy that does not allow the use of micro-macrowire electrodes.
• Cognitive/language skills insufficient to follow experimental instruction and maintain focus on the experiment.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Microwire electrodes

Experimental group

Description:

Activity of individual neurons will be recorded via microwire contacts. These microwire electrodes do not interfere with the macrowire clinical recordings.

Treatment:

Diagnostic Test: Microwire electrodes