Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

Stanford University

Status: Invitation-only

Conditions: Epilepsy

Treatments: Other: Cognitive experiment; Other: Electrical stimulation of the brain

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT07226908

1R01NS137650-01A1 (U.S. NIH Grant/Contract)

11354 (Registry Identifier)

Details and patient eligibility

About

The goal of the study is to examine how two key subregions of the human thalamus (ANT and PLV) are connected with other brain structures (Aim 1), how seizures involve the two thalamic subregions differently and how the map of cortico-thalamic ictal propagation matches the intrinsic connectivity maps identified in the same individuals (Aim 2), and the effect of ANT and PLV stimulations on memory formation (Aim 3).

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• No medical or surgical contraindication to electrode implantation
• Patient capable of understanding the scope of our project or signing informed consent independently

Exclusion criteria

• Unable to provide informed consent

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

100 participants in 1 patient group

Epilepsy Patients with Thalamic Electrode Implants

Other group

Description:

Patients will undergo cognitive testing and electrical stimulation experiments.

Treatment:

Other: Electrical stimulation of the brain

Other: Cognitive experiment