HUmanitas PROtontherapy (HU-PRO)

Istituto Clinico Humanitas

Status: Enrolling

Conditions: Proton Therapy; Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT07317245

PRO/OSS - 001/2026

Details and patient eligibility

About

Proton therapy is a cancer treatment, similar to the more commonly used radiation therapy. It uses radiation to destroy cancer cells and helps control the disease in the treated area.

However, when proton therapy is compared with standard radiation therapy, many studies show fewer side effects and better disease control. This is due to the unique physical properties of the particles used in proton therapy.

At present, in Italy, this innovative treatment is available only for selected diseases, as defined by national guidelines. For this reason, it is very important to collect as much data as possible to support the further development of proton therapy and to improve treatment safety and effectiveness.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Solid tumors candidate to proton therapy, in particular, according to Italian regolamentations
• Written informed consent for HU-PRO according to applicable legal and ethical requirements
• Indication for proton therapy
• ≥ 18 years old
• ECOG PS (performance status scale) 0-2

Exclusion criteria

• Age < 18 years old
• ECOG (performance status scale) >3
• Life expectancy < 3 months
• Inability to provide informed consent

Trial design

500 participants in 1 patient group

proton therapy

Description:

all patients treated with proton therapy according to clinical practice