Hunger, Satiety, and Metabolic Responses to High-fat Meals of Varying Fatty Acid Composition

Texas Christian University

Status: Unknown

Conditions: Body Weight Changes

Treatments: Other: PUFA-rich HF Meal; Other: MUFA-rich HF Meal; Other: SFA-rich HF Meal

Study type: Interventional

Funder types: Other

Identifiers

NCT02966444

CT2016JS1

Details and patient eligibility

About

This study evaluates the effects of dietary fatty acid composition from high fat meals on markers of hunger, satiety and metabolism.

Enrollment: 16 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI of >18.5-24.9kg/m2
• Woman
• 18-40yrs of age

Exclusion criteria

• Evidence of weight loss or gain exceeding 5% of their body weight within the past 3 months.
• Plans to lose weight or begin a weight loss program between initiation of study and final testing.
• Plans to begin an exercise program or change current exercise routines between initiation of study and final testing.
• Is on a medically prescribed diet
• Does not consume breakfast regularly
• Rate less than 80% of foods offered in the buffet at 50mm or more on the 100mm VAS as palatable
• Medications that could influence appetite or sensory function
• Reports of metabolic or endocrine disease, gastrointestinal disorders, or history of medical or surgical events that could affect fat digestion and hormone signaling.
• Any chronic disease including type II diabetes, hypothyroidism, hyperthyroidism, cardiovascular disease, and cancer
• Any supplements that a subject begins taking between initiation of study and final testing.
• Anyone who is currently pregnant, lactating, or planning on becoming pregnant before the conclusion of this study.
• Anyone who has allergies to any of the components of the liquid meals
• Anyone who has donated blood in the last 20 days

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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16 participants in 3 patient groups

MUFA-rich HF Meal

Experimental group

Description:

High-fat meal rich in monounsaturated fatty acids

Treatment:

Other: MUFA-rich HF Meal

PUFA-rich HF Meal

Experimental group

Description:

High-fat meal rich in polyunsaturated fatty acids

Treatment:

Other: PUFA-rich HF Meal

SFA-rich HF Meal

Experimental group

Description:

High-fat meal rich in saturated fatty acids

Treatment:

Other: SFA-rich HF Meal