Hyaluronic Acid and Amino Acid Combination Versus Exercise for Chronic Lateral Epicondylitis

Sivas State Hospital

Status: Active, not recruiting

Conditions: Lateral Epicondylitis

Treatments: Behavioral: Home Exercise Program; Drug: Hyaluronic Acid + Amino Acid Injection

Study type: Observational

Funder types: Other

Identifiers

NCT07410663

HA+AA-LE-001

Details and patient eligibility

About

This retrospective, controlled clinical study aims to evaluate the effectiveness of a targeted biological support injection containing a hyaluronic acid and amino acid combination in patients with chronic lateral epicondylitis (tennis elbow). Medical records will be reviewed to compare outcomes between patients treated in routine clinical practice with a 3-dose injection regimen (weeks 0, 2, and 4) plus a home exercise program and those treated with a home exercise program alone. Key outcome measures include pain intensity (VAS), functional status (PRTEE), grip strength, and pressure pain threshold.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged between 18 and 70 years.
• Patients diagnosed with Lateral Epicondylitis (LE).
• Presence of symptoms persisting for 6 weeks or longer.
• Patients who were treated with either a 3-dose protocol of Hyaluronic Acid + Amino Acid injection combined with a home exercise program, or a home exercise program alone.

Exclusion criteria

• History of rheumatic disease.
• History of malignancy.
• Presence of radiculopathy or neuropathy.
• Presence of peripheral circulatory disorders.
• Congenital or acquired upper extremity deformities.
• History of coagulopathy or current use of warfarin therapy.
• Presence of prosthesis, metal implant, or internal fixator in the elbow region.

Trial design

60 participants in 2 patient groups

Control Group: Home Exercise Program Only

Description:

Home exercise program without injection.

Treatment:

Behavioral: Home Exercise Program

Intervention Group: HA+AA Injection + Home Exercise Program

Description:

Patients in this retrospective cohort were treated with a targeted biological support injection (Hyaluronic Acid and Amino Acid combination) administered at weeks 0, 2, and 4, in addition to the standardized home exercise program.

Treatment:

Behavioral: Home Exercise Program

Drug: Hyaluronic Acid + Amino Acid Injection