Hyaluronic Acid Effect on Xenogenic Bone Healing

Saint-Joseph University

Status: Completed

Conditions: Tooth Loss; Bone Resorption

Treatments: Procedure: Ridge preservation: Tooth extration and immediat bone grafting in the socket

Study type: Interventional

Funder types: Other

Identifiers

NCT04377256

USJ-2019-267

Details and patient eligibility

About

The aim of this study is to test the hyaluronic acid hydrogel impact on the healing acceleration of xenogenic bone substitutes used in ridge preservation.

Following tooth extraction, bone particles are mixed with the hyaluronic acid gel and grafted in the tooth socket. at the implant placement phase, a cone beam computer assisted tomography file is recorded in order to compare it with the baseline and a biopsy to evaluate the histological consequences.

Enrollment: 7 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients in need of tooth extraction and willing to receive dental implants in the extraction site
• Presence of two mono radicular teeth in need of extraction

Exclusion criteria

• Patients with systemic diseases
• Patients under 8 years and above 60 years.
• Presence of endodontic or periodontal lesion in the extraction sites

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

---

7 participants in 2 patient groups

Radiological assessement

Experimental group

Description:

Two CBCTs were recorded and compared, one at the baseline and the other at 4 months post-op. The bone resorption was quantified and analyzed using ITK-SNAP software

Treatment:

Procedure: Ridge preservation: Tooth extration and immediat bone grafting in the socket

Histomorphometric analysis

Experimental group

Description:

During implant placement (4 months after the bone grafting), a bone biopsy is collected and stained with several colorants to analyze the biological bone healing

Treatment:

Procedure: Ridge preservation: Tooth extration and immediat bone grafting in the socket