Hyaluronic Acid Gel in Ridge Preservation

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Hyaluronic Acid Gel for Preservation the Extraction Socket

Treatments: Drug: Hyaluronic acid; Other: empty socket

Study type: Interventional

Funder types: Other

Identifiers

NCT06176937

FD-ASU-REC.852

Details and patient eligibility

About

hyaluronic acid gel applied at the extraction socket after extraction immediately to preserve the socket from post extraction resorption. hyaluronic acid has ability for osteogenesis and new bone formation.

Full description

twenty-four patients with one hopeless tooth at least, first CBCt before extraction to evaluate the dimension of the socket, then atraumatic extraction of the tooth to preserve the bony wall of the socket, after extraction and curettage the socket applied hyaluronic acid gel inside the socket and applied collagen membrane to secure the socket. After 4 months of extraction, CBCt was done to evaluate the dimension of the socket and the effect of hyaluronic acid. Furthermore, The core biopsy was taken by trephine bur at the time of implant placement for evaluate the histological appearance of the bone to evaluate the secondary outcome. then after three months the crown was delivered as a prosthetic part.

Enrollment: 24 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Healthy adult patients as evidenced by Burkett's oral medicine health history questionnaire

2. Both genders.

3. Age from 20 -50 years old.

4. Having at least one hopeless teeth indicated for extraction.

5. Esthetic zone teeth (anterior or premolar).

6. Sockets type 1 or 2 .

7. Patient should agree to sign a written consent after the nature of the study will be explained.

   Exclusion Criteria:

1- Smokers. 2- Pregnant and breast-feeding females. 3- Mentally retarded Patients. 4- Prisoners and handicapped patients. 5- Patients with malocclusion.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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24 participants in 2 patient groups

hyaluronic acid gel

Active Comparator group

Description:

Hyaluronic acid considers as a high molecular weight glycosaminoglycan (GAG) consists of multiple disaccharide non-sulfated units of D-glucuronic acid and N-acetylglucosamine

Treatment:

Drug: Hyaluronic acid

empty socket

Other group

Description:

extraction socket without application any drug

Treatment:

Other: empty socket