Hyaluronic Acid +Hydroxyapatite Vs Hydroxyapatite in Bone Regeneration

Cairo University (CU)

Status: Not yet enrolling

Conditions: Bone Lesion; Bone Loss

Treatments: Procedure: hyaluronic acid added to hydroxyapetite; Procedure: Hydroxyapatite alone

Study type: Interventional

Funder types: Other

Identifiers

NCT05957926

2991

Details and patient eligibility

About

Evaluation of the effect of hyaluronic acid with hydroxyapatite versus hydroxyapatite alone on bone regeneration following enucleation of mandibular odontogenic cyst.

Full description

During cyst enucleation , There's resultant decrease in bone density especially in large defects .Therefore, it may be needed for a bone grafts and bone regenerative materials to improve quality of bone .The rationale is to evaluate hyaluronic acid with hydroxyapatite as a bone quality improvement material following cyst enucleation, which would provide significant bone regeneration. Hydroxyapatite is inorganic component of bone tissue used as bone graft, scaffolds, filler and cement for repair and regeneration of bone defect , and it is stimulate bone remodeling by generating surface active moieties or cell signaling process while Hyaluronic acid and it's derivatives has been widely used for bone regeneration and it has a good potential for osteogenesis and mineralization

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patient in need of cyst removal .
• Both genders aged between 18-50 years .
• Size of lesion is ≤ 4 cm .
• Patients free from any systemic disease that may affect bone healing .

Exclusion criteria :

• Heavy smokers , alcohol intake .
• Poor oral hygiene .
• Patient with systemic disease that may affect bone healing .
• Pregnant women.
• Patient who are currently or have been under treatment using chemotherapy or radiotherapy
• Uncooperative patient .

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

20 participants in 2 patient groups

Hyaluronic acid + Hydroxyapatite

Experimental group

Description:

hyaluronic acid is used for bone regeneration and it has a good potential for osteogenesis and mineralization so it can have synergistic effect when used with hydroxyapatite for bone regeneration after cyst enucleation

Treatment:

Procedure: hyaluronic acid added to hydroxyapetite

Hydroxyapatite alone

Active Comparator group

Description:

Hydroxyapatite is inorganic component of bone tissue used as bone graft, scaffolds, filler and cement for repair and regeneration of bone defect , and it stimulates bone remodeling by generating surface active moieties or cell signaling process

Treatment:

Procedure: Hydroxyapatite alone