Hyaluronic Acid in Counteracting Aphthous Stomatitis

University of Urbino "Carlo Bo"

Status: Completed

Conditions: Aphthous Stomatitis

Treatments: Drug: Chlorhexidine Gluconate; Device: Hyaluronic acid-based gel

Study type: Observational

Funder types: Other

Identifiers

NCT04884464

UniUrb_HyalAcid_2021

Details and patient eligibility

About

Oral mucosal ulcers can determine a real worsening of the quality of life. Conventional therapy usually lasts not less than 2-3 weeks, and carries a high risk of serious side effects; furthermore, ulcers often recur. The use of hyaluronic acid applied as an adhesive gel over the lesions seems to have potential in terms of efficacy and the avoidance of side effects. Of course, hyaluronic acid-based formulations show different effects and tolerability. In this retrospective observational study, the results obtained using a hyaluronic-acid based medical device applied for 14 days to counteract ulcers in adults will be reported.

Enrollment: 49 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of aphthous stomatitis
• Healthy for other conditions excluding aphthous stomatitis

Exclusion criteria

• Taking one of the following in the 45 days prior to the beginning of the study: immunosuppressive, cytotoxic, cortisone, antibiotic, antifungal, hormone therapy (including birth control pills).

Trial design

49 participants in 2 patient groups

Hyaluronic acid-based gel

Description:

The composition of the gel, ranked by weight is: xylitol, glycerin, Rosa damascena petal extract, xanthan gum, polycarbophil, hyaluronic acid sodium salt (0.24%), pectin, potassium sorbate, sodium benzoate, panthenol, Aloe barbadensis leaf extract, stevia.

Treatment:

Device: Hyaluronic acid-based gel

Chlorhexidine gluconate

Description:

Chlorhexidine gluconate at a concentration of 0.2%.

Treatment:

Drug: Chlorhexidine Gluconate