Comparative Evaluation of Hyaluronic Acid Spray and Low-Level Laser Therapy on Wound Healing Following Gingivectomy: A Randomized, Noninferiority Trial

Akdeniz University

Status: Completed

Conditions: Gingival Enlargement

Treatments: Other: Gengigel Spray; Other: Low Level Laser Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT07034625

AkdenizU1

Details and patient eligibility

About

Gingival enlargement is a common condition caused by increased cell numbers, leading to connective tissue expansion. It can hinder plaque control and cause aesthetic and functional problems, often requiring surgical intervention. Gingivectomy is the primary procedure for treating gingival enlargement, ensuring periodontal health. Postoperative low-level laser therapy (LLLT) may reduce inflammation, relieve pain, and accelerate tissue regeneration. Similarly, hyaluronic acid (HA) stimulates cell proliferation, migration, and differentiation, promoting wound healing. This study aimed to compare the effects of LLLT and HA spray on early wound healing after gingivectomy.

Enrollment: 64 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Systemically healthy
• Having chronic inflammatory gingival hyperplasia affecting at least 6 teeth symmetrically in the maxillary or mandibular anterior region with gingivectomy indication
• No usage of any medication affecting periodontal tissues or causing gingival hyperplasia such as antiepileptics, immunosupresors or calcium channel blockers
• No history of periodontitis with attachment and bone loss

Exclusion criteria

• Having systemic disease
• Pregnancy or breastfeeding
• Smoking
• Inadequate oral hygiene
• Antibiotic usage for the past six months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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64 participants in 2 patient groups

Low level laser therapy

Active Comparator group

Description:

After gingivectomy surgery, 940 nm wavelength diode laser was applied to the wound area on the surgery day, 3rd, 5th and 7th days postoperatively. The power of the laser was set to 3W, power density 1.07 W/cm2, probe spot size 2.8 cm2, application mode continuous wave, application distance 1mm and application type stable.

Treatment:

Other: Low Level Laser Therapy

Hyaluronic Acid Spray

Active Comparator group

Description:

After gingivectomy surgery, patients were given a high molecular weight hyaluronic acid spray and instructions for use were explained. Accordingly, the patients applied the spray to the wound area twice a day for the first 7 days.

Treatment:

Other: Gengigel Spray