Hyaluronic Acid Treatment of the Post-extraction Tooth Socket Healing in Subjects With Diabetes Mellitus Type 2

University of Turin

Status

Completed

Conditions

Delayed Wound Healing

Diabetes Mellitus, Type 2

Tooth Extraction Status Nos

Treatments

Device: Hyaluronic acid gel

Study type

Interventional

Funder types

Other

Identifiers

NCT05896319

Unito-DM2022

Details and patient eligibility

About

The aim of the present split-mouth study was to investigate the effect of Hyaluronic Acid (HA) in improving the post-extraction tooth socket healing in subjects with diabetes mellitus type 2.

The null hypothesis was that HA can significantly improve the post extractive healing of diabetic patients compared with no treatment.

36 patients with diabetes mellitus type 2 requiring bilateral extraction of the homologous, not included, teeth were enrolled. After the extractions carried out in the same appointment, following the split-mouth design of the study, one site was randomly assigned to the test (T) group, while the other one was assigned to the control group (C).

T group included: Post-operative application of Hyaluronic acid gels 3 times per day

C group included: no treatment.

Patients were then followed after 3, 7,14 and 21 days and the healing of each socket was evaluated and compared between the 2 groups.

Enrollment

36 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age ≥ 18 years old
diabetic type 2 patients with glycaemia levels under control but with a positive history for diabetes complications (e.g., nephropathy, neuropathy, retinopathy, cardiopathy, peripheral vascular disease)
agreement to be enrolled in the study
availability to come at the control visit

Exclusion criteria