Hyaluronic Acid With Connective Tissue Grafting for Gingival Recession

Saglik Bilimleri Universitesi

Status: Active, not recruiting

Conditions: Gingival Recession

Treatments: Procedure: Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF); Biological: Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only).

Study type: Interventional

Funder types: Other

Identifiers

NCT07291583

Seyma9319

Details and patient eligibility

About

This study evaluates whether adding 0.8% hyaluronic acid (HA) to connective tissue grafting and coronally advanced flap surgery improves clinical and esthetic outcomes in the treatment of gingival recession. Adult patients with Miller I-II or Cairo RT1 recession defects will be randomly assigned to receive CTG alone or CTG with adjunctive HA. Mean root coverage at 6 months is the primary outcome, while secondary measures include gingival thickness, clinical attachment level, esthetic scores, postoperative morbidity, and quality of life. The study aims to determine whether HA enhances soft tissue healing and root coverage predictability compared with conventional CTG.

Enrollment: 40 patients

Sex: All

Ages: 18+ months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Presence of at least one gingival recession defect classified as Cairo RT1 or Miller Class I-II with a minimum depth of 1 mm.
• Full-mouth plaque score (FMPS) and full-mouth bleeding on probing (FMBOP) < 15%.
• Detectable cemento-enamel junction (CEJ).
• Age ≥ 18 years.
• No history of prior periodontal surgical treatment.
• Sufficient mental capacity to understand the study aims and procedures explained verbally and in writing.
• Determined to be cooperative and compliant with the clinician before, during, and after the surgical procedure.

Exclusion criteria

• Patients younger than 18 years.
• Periodontally healthy individuals.
• Current smokers.
• History of periodontal treatment within the past 1 year.
• Use of antibiotics within the past 3 months.
• Pregnancy or breastfeeding.
• Presence of systemic diseases such as diabetes, chronic kidney failure, cancer, bleeding disorders, connective tissue diseases, or other chronic conditions; and gingival recessions classified as Cairo RT3.
• Presence of cervical caries or restorations at the defect site.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 2 patient groups

Experimental - CTG + Hyaluronic Acid

Experimental group

Description:

A 0.8% hyaluronic acid (HA) gel is applied to the connective tissue graft (CTG) before flap closure during the coronally advanced flap (CAF) procedure. The HA gel is used as an adjunctive biologic material to potentially enhance wound healing, soft tissue thickness, esthetic outcomes, and overall root coverage performance.

Treatment:

Biological: Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only).

Procedure: Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)

CTG only

Active Comparator group

Description:

A standardized coronally advanced flap (CAF) procedure combined with a subepithelial connective tissue graft (CTG) is performed to treat gingival recession defects. The surgical protocol includes flap elevation, graft harvesting and placement, and flap advancement and suturing.

Treatment:

Procedure: Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)