Hydrochlorothiazide (+) Losartan Potassium vs. Amlodipine Comparative Study (0954A-314)

Organon

Status and phase: Completed; Phase 4

Conditions: Essential Hypertension

Treatments: Drug: MK0954A; hydrochlorothiazide (+) losartan potassium / Duration of Treatment: 12 weeks

Study type: Interventional

Funder types: Industry

Identifiers

NCT00157963

2005_067

0954A-314

Details and patient eligibility

About

An efficacy and safety study of hydrochlorothiazide (+) losartan potassium compared to amlodipine at week 12 in Korean patients with essential hypertension

Enrollment: 174 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of age 20 70 75 with essential hypertension
• SiDBP 90 ~ 114mmHg at V1 & V2

Exclusion criteria

• Patient has known or suspected secondary hypertension
• Patient has a history of malignant hypertension (SiSBP > 210mmHg)
• Individuals has a known sensitivity or intolerance to HCTZ or any AIIAs, or any sulfonamide-derived drugs.
• Patient has shown significant abnormal laboratory evaluations

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)