Hydrogen-Rich Water and Metabolic Health in Adults: A 12-Week Randomized Trial (HYDRO-RESPOND)

University of Novi Sad, Faculty of Sport and Physical Education

Status: Completed

Conditions: Metabolic Syndrome

Treatments: Dietary Supplement: Experimental 2: high-breath hydrogen; Dietary Supplement: Experimental 1: low-breath hydrogen; Dietary Supplement: Experimental 4: high-breath hydrogen; Dietary Supplement: Experimental 3: low-breath hydrogen

Study type: Interventional

Funder types: Other

Identifiers

NCT06968715

51-02-01

Details and patient eligibility

About

The HYDRO-RESPOND trial is a 12-week randomized controlled study investigating the effects of daily hydrogen-rich water (HRW) consumption on body composition and metabolic biomarkers in adults diagnosed with metabolic syndrome. The study also explores whether individual differences in baseline breath hydrogen levels influence response to HRW. Participants are randomly assigned to receive either HRW or a placebo, with outcomes including changes in body fat, waist circumference, glucose metabolism, lipid profiles, and inflammatory markers. The trial aims to determine the therapeutic potential of HRW and identify predictors of individual responsiveness.

Enrollment: 40 patients

Sex: All

Ages: 30 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 30-65 years

• Metabolic syndrome (NHS) (at least 3 of the 5 following criteria):

  • Waist circumference of ≥ 102 cm in men and ≥ 88 cm in women
  • Hypertriglyceridemia (≥ 1.695 mmol/L)
  • Low HDL-C (< 1.04 mmol/dL in men and < 1.30 mmol/dL in women)
  • High blood pressure (> 130/85 mmHg)
  • High fasting glucose (> 6.1 mmol/L)

• Not physically active

• Informed consent signed

Exclusion criteria

• Major chronic disease and acute injuries
• History of dietary supplement use during the past 4 weeks
• History of metabolism-modulating pharmaceuticals use during the past 4 weeks
• No consent to randomization
• Participation in other studies

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 4 patient groups, including a placebo group

Experimental 1: low-breath hydrogen

Experimental group

Description:

One liter of hydrogen-rich water per day

Treatment:

Dietary Supplement: Experimental 1: low-breath hydrogen

Experimental 2: high-breath hydrogen

Experimental group

Description:

One liter of hydrogen-rich water per day

Treatment:

Dietary Supplement: Experimental 2: high-breath hydrogen

Experimental 3: low-breath hydrogen

Placebo Comparator group

Description:

One liter of control water per day

Treatment:

Dietary Supplement: Experimental 3: low-breath hydrogen

Experimental 4: high-breath hydrogen

Placebo Comparator group

Description:

One liter of control water per day

Treatment:

Dietary Supplement: Experimental 4: high-breath hydrogen