Hydrogen-Rich Water and Resting Metabolism in Young Adults (H2REST)

University of Novi Sad

Status: Not yet enrolling

Conditions: Healthy Subjects or Volunteers

Treatments: Dietary Supplement: Molecular Hydrogen; Dietary Supplement: Placebo Comparator

Study type: Interventional

Funder types: Other

Identifiers

NCT07098221

50-10-18/2024-3

Details and patient eligibility

About

The H2REST trial is a randomized, double-blind, placebo-controlled crossover study investigating the acute effects of a single dose of hydrogen-rich water (HRW) on resting metabolism in healthy young adults. Participants complete two testing sessions-receiving either HRW or placebo in a randomized order-followed by standardized metabolic testing. Primary outcomes include resting energy expenditure, respiratory exchange ratio, and substrate utilization measured via indirect calorimetry. The study aims to assess whether acute HRW intake can modulate metabolic rate and fuel preference at rest, and to explore inter-individual variability in response.

Enrollment: 24 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18-35 years
• BMI between 18.5 and 25.0 kg/m²
• Apparently healthy, with no history of chronic disease
• Non-smoker, not currently using nicotine-containing products
• Able to provide informed consent
• Willing to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each study visit
• Able to comply with study procedures, including fasting and attending all study visits

Exclusion criteria

• Diagnosed metabolic, cardiovascular, respiratory, gastrointestinal, or endocrine disorders
• Use of dietary supplements or medications affecting metabolism (within the past 2 weeks)
• Allergy or intolerance to components of the hydrogen or placebo beverages
• Pregnant or lactating
• Shift work or irregular sleep schedule
• Participation in another clinical study within the past 30 days

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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24 participants in 2 patient groups, including a placebo group

ARM1: 250 ml of Hydrogen Rich Water

Experimental group

Description:

Hydrogen-producing tablets: Tablets designed to dissolve in water and release molecular hydrogen gas, creating hydrogen-rich water that can be consumed to potentially provide antioxidant and anti-inflammatory benefits.

Treatment:

Dietary Supplement: Molecular Hydrogen

ARM 2: 250 ml of Placebo Water (Non-hydrogen-producing tablets)

Placebo Comparator group

Description:

Non-hydrogen-producing tablets, identical in appearance and taste to the active supplement

Treatment:

Dietary Supplement: Placebo Comparator