Hydrolyzed Collagen and Undenatured Collagen Type II in OA Knee

Prince of Songkla University

Status: Not yet enrolling

Conditions: Osteo Arthritis Knee

Treatments: Other: Placebo; Dietary Supplement: Collagen

Study type: Interventional

Funder types: Other

Identifiers

NCT06229951

66-304-11-1

Details and patient eligibility

About

Randomized controlled trial

Targeted patients who come to receive treatment for osteoarthritis that meets the research indications will be assigned to a random group by the box of 4 randomization method, with a sequence that is randomly generated by a computer. The groups are divided into two groups:

Group 1: Patients who have taken 480 mg of hydrolyzed collagen and 20 mg of undenatured type II collagen

Group 2: Control patients will take placebo

Primary outcome : Pain level

Enrollment: 68 estimated patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age: 50-80 years old
• Medial compartment knee osteoarthritis
• Kellgren and Lawrence classification stage 2 -3
• Able to walk without walking aid

Exclusion criteria

• History of knee surgery on the study side
• History of intra-articular steroid injection within 6 months prior to study entry
• Systemic arthritis conditions
• Degenerative neurological and muscular conditions in the lower extremities
• Chronic kidney disease with CrCl < 30 ml/min

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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68 participants in 2 patient groups, including a placebo group

Collagen supplement group

Experimental group

Description:

Patients who have taken 480 mg of hydrolyzed collagen and 20 mg of undenatured type II collagen (in one tablet) twice a day

Treatment:

Dietary Supplement: Collagen

Control group

Placebo Comparator group

Description:

Control patients will take placebo twice a day

Treatment:

Other: Placebo